Mathematical simulation of cerebral blood flow in focal ischemia.
نویسندگان
چکیده
منابع مشابه
Mathematical simulation of cerebral blood flow in focal ischemia.
A computer model was developed to describe regional cerebral blood flow and tissue oxygenation with autoregulation during focal ischemia produced by occlusion of th middle cerebral artery (MCA). This steady state model described the distribution of blood flow in the cerebral arterial system including the circle of Willis as well as the pial arterial anastomoses, and included a simplified form o...
متن کاملCerebral Blood Flow in Focal Ischemia
A comparison of regional cerebral blood flow measurements made with betaand gamma-emitting isotopes revealed good correspondence in areas of normal perfusion and reactive hyperemia but poor correspondence in areas of focal ischemia. After middle cerebral artery occlusion at normocapnia, there was a 65% reduction in regional cerebral blood flow from 1.40 ± 0.27 ml/g min~' to 0.49 ± 0.10 ml/g min...
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Introduction: Development of brain edema following focal cerebral ischemia exacerbates primary ischemic injury. Blood brain barrier (BBB) opening is an important part of edema named as vasogenic brain edema. In this study, quantitative alterations of BBB permeability is experimentally evaluated using transient focal cerebral ischemia in the rat. Methods: Two groups of male rats (ischemic and sh...
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background & objectives: ischemic stroke is the third leading cause of death and disability in most of the human societies. there is no effective treatment due to complexity of the pathophysiological mechanisms. today, more researches are designed to introduce involving factors and new treatment strategies in brain ischemia. the objective of this study is to introduce an experimental model of t...
متن کاملTime course of cerebral blood flow and histological outcome after focal cerebral ischemia in rats.
BACKGROUND AND PURPOSE The relation between time-dependent changes in cerebral blood flow and the appearance of infarction after focal cerebral ischemia is still a matter for debate. The aim of this study was to measure perfusion after simultaneous occlusions of the left middle cerebral artery and ipsilateral common carotid artery in rats and correlate it with the timing and distribution of his...
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ژورنال
عنوان ژورنال: Stroke
سال: 1982
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.13.5.693